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Statements Author contributions GD and KK conceived the study and wrote the manuscript

2.2 Data acquisition MRI: All data were collected on a Philips 3T Ingenia Elition RX scanner (Philips Healthcare, Best, the Netherlands) equipped with a 32-channel receive-only head coil

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Split dosing can divide daily doses into two smaller injections (1 mg morning + 1 mg evening) for targeted healing and more stable blood levels throughout the day